Team - SYNSIGHT

EXECUTIVE TEAM

Cyril BAUVAIS

Cyril is a co-founder of Synsight. He is specialized in Biological Macromolecule Modeling and in Chemoinformatics.

He obtained his PhD in Molecular Modeling and Theoretical Chemistry at the University Paris-Diderot, Paris VII (group of B.T. Fan), before undertaking post-doctoral studies at the Pharmacy University of Chatenay-Malabry, France (BIOCIS lab) and at Heidelberg University, Germany (the Computational Molecular Biophysics group). Before establishing Synsight, he worked at Bioquanta, a biotech company in Paris, where he oversaw development of in silico methods for toxicity prediction.

Guillaume BOLLOT

Guillaume is a co-founder of Synsight. He is specialized in Protein & Enzyme Design and in Quantum Chemistry.

He obtained his PhD in Computational Chemistry and Molecular Modeling at the University of Geneva, Switzerland (group of J. Mareda), where he studied notably organic reactions, antibody catalytic reactions and artificial transmembrane pores. During his postdoctoral research at the University of California, Los Angeles (group of K. Houk), he studied enzyme design, enzymatic catalysis and prediction of new enzyme structures. Upon returning to his native France, Guillaume joined the biotech company Bioquanta, where he headed the in silico platform in Molecular Modeling and acquired pharmaceutical research experience. He later co-founded SynSight.

Advisory Board

Patrick CURMI

Patrick Curmi is president of the University of Evry-val d’Essonne and previously served as director of the Structure and Activity of Normal and Pathological Biomolecules (SABNP) laboratory at INSERM. After postdoctoral research in Molecular Biology(Institut du Fer à Moulin, Andre Sobel’s lab), he developed the conditions that led to the discovery, in 2000, of the atomic structure of tubulin, a protein essential for cell division, many morphogenetic processes and intracellular communication. As director of the SABNP lab, Dr. Curmi continued his research on the atomic structure of proteins important for human health, working at the interface of Biology and Nanoscience. He has authored numerous international publications. Patrick Curmi is a member of the board member at the Neuroscience research pole Neuropôle Francilien (Île-de-France, France) and is a reviewer for many peer-reviewed international journals.
Dr. Curmi helps define Synsight’s R&D strategy.

Joseph ANDRÉ

Joseph André spent 3 years at a biotechnology company (Bioquanta, France) as a researcher and then earned a PhD in Bioinformatics at the Université d’Evry-Val-d’Essone, where he specialized in Protein Modeling and Drug Design. He gained a strong experience in biotech industry Project Management and developed a close relationship with the SABNP laboratory at INSERM/Université d’Evry-Val-d’Essonne.

Patrick AUGIER DE MOUSSAC

Patrick Augier de Moussac holds an MBA. In 1987, he founded the Biomedical Diagnostics company currently known as Theradiag. Patrick Augier de Moussac is Synsight’s business mentor. He contributes to major strategic decisions and directions for Synsight.

Publications

Blondel, S.; Egesipe A.L.; Picardi, P.; Jaskowiak, A.L.; Notarnicola, M.; Ragot, J.; Tournois, J.; Le Corf, A.; Brinon, B.; Poydenot, P.; Georges, P.; Navarro, C.; Pitrez, P.R.; Ferreira, L.; Bollot, G.; Bauvais, C.; Laustriat, D.; Mejat, A.; De Sandre-Giovannoli, A.; Levy, N.; Bifulco, M.; Peschanski, M.; Nissan, X.
“Drug screening on Hutchinson Gilford progeria pluripotent stem cells reveals aminopyrimidines as new modulators of farnesylation.”
Cell Death Dis. 2016 Feb 18;7:e2105.

Sari-Hassoun, M.; Clement, M.J.; Hamdi, I.; Bollot, G.; Bauvais, C.; Joshi, V.; Toma, F.; Burgo, A.; Cailleret, M.; Rosales-Hernández, M.C.; Macias Pérez, M.E.; Chabane-Sari, D.; Curmi, P.A.
“Cucurbitacin I elicits the formation of actin/phospho-myosin II co-aggregates by stimulation of the RhoA/ROCK pathway and inhibition of LIM-kinase.”
Biochem Pharmacol. 2016 Feb 15;102:45-63.

Parker, M.F.; Osuna, S.; Bollot, G.; Vaddypally, S.; Zdilla, M.J.; Houk, K.N.; Schafmeister, C.E.
“Acceleration of an Aromatic Claisen Rearrangement via a Designed Spiroligozyme Catalyst that Mimics the Ketosteroid Isomerase Catalytic Dyad”
J. Am. Chem. Soc. 2014, 136(10), 3817-3827.

Osuna, S.; Kim, S.; Bollot, G.; Houk, K.N.
“Aromatic Claisen Rearrangements of O-prenylated tyrosine and model prenyl aryl ethers: Computational study of the role of water on acceleration of Claisen rearrangements”
European J. Org. Chem. 2013, 2013(14).

Bordessa, A.; Keita, M.; Maréchal, X.; Formicola, L.; Lagarde, N.; Rodrigo, J.; Bernadat, G.; Bauvais, C.; Soulier, J.-L.; Dufau, L.; Milcent, T.; Crousse, B.; Reboud-Ravaux, M.; Ongeri, S.
“alpha and beta-hydrazino acid-based pseudopeptides inhibit the chymotrypsin-like activity of the eukaryotic 20S proteasome”
European Journal of Medicinal Chemistry 70, 2013, 505

Hercend, C.; Bauvais, C.; Bollot, G.; Delacotte, N.; Chappuis, P.; Woimant, F.; Launay, J.-M.; Manivet, P.
“Elucidation of the ATP7B N-domain Mg2+-ATP Coordination Site and its Allosteric Regulation”
PLoS ONE 2011, 6(10), e26245.

Fürstenberg, A.; Kel, O.; Gradinaru, J.; Ward, T. R.; Emery, D.; Bollot, G.; Mareda, J.; Vauthey, E.
“Site-dependent excited-state dynamics of a fluorescent probe bound to avidin and streptavidin”
ChemPhysChem 2009, 10, 1517-1532.

Covers, by Guillaume Bollot

Sulzer-Mossé, S.; Alexakis, A.; Mareda, J.; Bollot, G.; Bernardinelli, G.; Filinchuk, Y.
“Enantioselective Organocatalytic Conjugate Addition of Aldehydes to Vinyl Sulfones and Vinyl Phosphonates as Challenging Michael Acceptors”
Chem. Eur. J. 2009, 15, 3204-3220.

Kishore, R.S.; Kel, O.; Banerji, N.; Emery, D.; Bollot, G.; Mareda, J.; Gomez-Casado, A.; Jonkheijm, P.; Huskens, J.; Maroni, P.; Borkovec, M.; Vauthey, E.; Sakai, N.; Matile, S.
“Ordered and oriented supramolecular n/p-heterojunction surface architectures: completion of the primary color collection”
J. Am. Chem. Soc. 2009, 131(31), 11106-11116.

Banerji, N.; Bhosale, R.; Bollot, G.; Butterfield, S. M.; Fürstenberg, A.; Gorteau, V.; Hagihara, S.; Hennig, A.; Maity, S.; Mareda, J.; Matile, S.; Mora, F.; Perez-Velasco, A.; Ravikumar, V.; Kishore, R. S. K.; Sakai, N.; Tran, D.-H.; Vauthey, E.
“Artificial Tongues and Leaves”
Pure Appl. Chem. 2008, 80, 1873-1882.

Hagihara, S.; Gremaud, L.; Bollot, G.; Mareda, J.; Matile, S.
“Screening of π-Basic Naphthalene and Anthracene Amplifiers for π-Acidic Synthetic Pore Sensors”
J. Am. Chem. Soc. 2008, 130, 4347-4351.

Gorteau, V.; Bollot, G.; Mareda, J.; Matile, S.
“Rigid-Rod Anion-π Slides for Multiion Hopping across Lipid Bilayers”
Org. Biomol. Chem. 2007, 5, 3000-3012

Tanaka, H.; Bollot, G.; Mareda, J.; Litvinchuk, S.; Tran, D.-H.; Sakai, N.; Matile, S.
“Synthetic Pores with Sticky π-Clamps”
Org. Biomol. Chem. 2007, 5, 1369-1380.

Litvinchuk, S.; Tanaka, H.; Miyatake, T.; Pasini, D.; Tanaka, T.; Bollot, G.; Mareda, J.; Matile, S.
“Synthetic Pores with Reactive Signal Amplifiers as Artificial Tongues”
Nature Materials 2007, 6, 576-580.

Bhosale, R.; Bhosale, S.; Bollot, G.; Gorteau, V.; Julliard, M. D.; Litvinchuk, S.; Mareda, J.; Matile, S.; Miyatake, T.; Mora, F.; Perez-Velasco, A.; Sakai, N.; Sisson, A. L.; Tanaka, H.; Tran, D.-H.
“Synthetic Multifunctional Nanoarchitecture in Lipid Bilayers: Ion Channels, Sensors, and Photosystems”
Bull. Chem. Soc. Jpn. 2007, 80, 1044-1057.

Bauvais, C.; Barbault, F.; Petitjean, M.; Zhu, Y.; Fan, B.T.
“Elucidation of chiral recognition processes of macrocyclic antibiotic vancomycin”
SAR and QSAR in Environmental Research 2006, 17, 3, 253–264

Deniau, G.; Charlier, J.; Alvado, B.; Aplincourt, P.; Bauvais, C.; Palacin, S
.“Study of the simultaneous electro-initiated anionic polymerization of vinylic molecules”
Journal of Electroanalytical Chemistry 2006, 586, 62–71

Tanaka, H.; Litvinchuk, S.; Tran, D.-H.; Bollot, G.; Mareda, J.; Sakai, N.; Matile, S.
“Adhesive π-Clamping within Synthetic Multifunctional Pores”
J. Am. Chem. Soc. 2006, 128, 16000-16001.

Gorteau, V.; Bollot, G.; Mareda, J.; Perez-Velasco, A.; Matile, S.
“Rigid Oligonaphthalenediimide Rods as Transmembrane Anion-π Slides”
J. Am. Chem. Soc. 2006, 128, 14788-14789.

Bhosale, S.; Sisson, A. L.; Talukdar, P.; Fürstenberg, A.; Banerji, N.; Vauthey, E.; Bollot, G.; Mareda, J.; Röger, C.; Würthner, F.; Sakai, N.; Matile, S.
“Photoproduction of Proton Gradients with π-Stacked Fluorophore Scaffolds in Lipid Bilayers”
Science 2006, 313, 84-86.

Baudry, Y.; Bollot, G.; Gorteau, V.; Litvinchuk, S.; Mareda, J.; Nishihara, M.; Pasini, D.; Perret, F.; Ronan, D.; Sakai, N.; Shah, M. R.; Som, A.; Sordé, N.; Talukdar, P.; Tran, D.-H.; Matile, S.
“Molecular Recognition by Synthetic Multifunctional Pores in Practice: Are Structural Studies Really Helpful?”
Adv. Func. Mater. 2006, 16, 169-179.

Talukdar, P.; Bollot, G.; Mareda, J.; Sakai, N.; Matile, S.
“Ligand-Gated Synthetic Ion Channels”
Chem. Eur. J. 2005, 11, 6525-6532.

Kumaki, J.; Yashima, E.; Bollot, G.; Mareda, J.; Litvinchuk, S.; Matile, S.
“AFM Snapshots of Synthetic Multifunctional Pores with Polyacetylene Blockers: Pseudorotaxanes and Template Effects”
Angew. Chem. Int. Ed. 2005, 44, 6154-6157.

Bollot, G.; Fouillet, C. C. J.; Mareda, J.
“Modeling of Solvolysis Reaction Mechanism for Cation-Olefin Cyclizations”
Chimia 2005, 59, 97-100.

Gorteau, V.; Bollot, G.; Mareda, J.; Pasini, D.; Tran, D.-H.; Lazar, A. N.; Coleman, A. W.; Sakai, N.; Matile, S. “Synthetic Multifunctional Pores that Open and Close in Response to Chemical Stimulation”
Bioorg. Med. Chem. 2005, 13, 5171-5180.

Talukdar, P.; Bollot, G.; Mareda, J.; Sakai, N.; Matile, S.
“Synthetic Ion Channels with Rigid-Rod π-Stack Architecture that Open in Response to Charge-Transfer Complex Formation”
J. Am. Chem. Soc. 2005, 127, 6528-6529.

Gorteau, V.; Perret, F.; Bollot, G.; Mareda, J.; Lazar, A. N.; Coleman, A. W.; Tran, D.-H.; Sakai, N.; Matile, S. “Synthetic Multifunctional Pores with External and Internal Active Sites for Ligand Gating and Noncompetitive Blockage”
J. Am. Chem. Soc. 2004, 126, 13592-13593.

Litvinchuk, S.; Bollot, G.; Mareda, J.; Som, A.; Ronan, D.; Shah, M. R.; Perrottet, P.; Sakai, N.; Matile, S.
“Thermodynamic and Kinetic Stability of Synthetic Multifunctional Rigid-Rod β-Barrel Pores: Evidence for Supramolecular Catalysis”
J. Am. Chem. Soc. 2004, 126, 10067-10075.

Chandrappa, G.T.; Steunou, N.; Cassaignon, S.; Bauvais, C.; Livage, J.
“Hydrothermal synthesis of vanadium oxide nanotubes from V2O5 gels”
Catalysis Today 2003, 78, 85–89

Chandrappa, G.T.; Steunou, N.; Cassaignon, S.; Bauvais, C.; Biswas, P.K.; Livage, J.
“Vanadium oxide: From gels to nanotubes”
Journal of Sol-Gel Science and Technology 2003, 26, 1-3, 593-596